Direct supply from Xi'an Sirn Bio-Tech's cGMP workshops. Assayed via HPLC/GC-MS, compliant with the Japanese Positive List System for agricultural chemical residues, and tailored for pilot to industrial-scale production.
The Greater Yokohama industrial metropolitan area—anchoring the Kanagawa industrial corridor and the Keihin Maritime Logistics Cluster—represents one of East Asia's most sophisticated manufacturing hubs for nutraceutical finished dosage forms, functional beverages, and high-performance quasi-drug skincare. As brands based throughout Minato Mirai R&D centers, Kohoku New Town, and Kawasaki manufacturing zones navigate accelerating consumer scrutiny under Japan's Consumer Affairs Agency (CAA), raw material procurement teams require far more than transactional spot sourcing. They require audited traceability, rigorous validation under the Japanese Pharmacopoeia (JP XVII/XVIII), and definitive compliance with the Ministry of Health, Labour and Welfare (MHLW) Positive List System for agricultural residues.
Strategic Yokohama Logistics Gateway: Utilizing container freight berths at Honmoku and Daikoku Pier terminals in the Port of Yokohama, Xi'an Sirn Bio-Tech maintains bonded maritime customs channels directly connecting Shaanxi botanical origin production with Kanagawa manufacturing plants, cutting regional lead times to 7–10 days with complete temperature-controlled container security.
Formulating within the Japanese regulatory framework leaves zero tolerance for botanical adulteration, variable active yields, or residual chemical solvents. Every botanical extract manufactured by Xi'an Sirn Bio-Tech destined for Yokohama port delivery undergoes dual-gate chromatography screening. In our central testing lab—augmented by joint research centers alongside Xi'an Jiaotong University and Northwest University—we quantify active markers such as cordycepin, oleuropein, and natural polyphenols through High-Performance Liquid Chromatography (HPLC) with photodiode array detection, while volatile pesticide traces are screened using Gas Chromatography-Tandem Mass Spectrometry (GC-MS/MS).
For brands registering products under Kinō-sei Hyōji Shokuhin (Foods with Function Claims), consistency in batch-to-batch standardized marker compounds is mandatory to satisfy CAA scientific substantiation protocols. Our botanical extraction process avoids harsh halogenated hydrocarbons, employing clean hydroethanolic solvents and subcritical low-temperature vacuum evaporation to protect thermolabile phytochemical profiles while guaranteeing zero residual solvent peaks on release testing.
| Analytical Parameter | Sirn Bio-Tech Standard | Japanese MHLW / JP XVII Limit | Analytical Method |
|---|---|---|---|
| Heavy Metals (as Pb) | < 5.0 ppm (lot typical < 1.0 ppm) | ≤ 10.0–20.0 ppm | ICP-MS (Inductively Coupled Plasma) |
| Arsenic (As) | < 1.0 ppm (lot typical < 0.3 ppm) | ≤ 2.0 ppm | Hydride Generation ICP-MS |
| Pesticide Multi-Residue | Zero Detectable above 0.01 mg/kg limit | Positive List Default ≤ 0.01 ppm | GC-MS/MS & LC-MS/MS (450+ Screen) |
| Irradiation (Sterilization) | Strictly Irradiation-Free (100% Negative) | Irradiation Prohibited for Food Use | TL / PSL Thermoluminescence Test |
| Microbiological (Total Aerobic) | < 1,000 CFU/g (Extract) / < 100 CFU/g (Cosmetic) | ≤ 3,000 CFU/g | JP Microbial Limit Testing (Membrane) |
| Carrier Matrix & Excipients | Non-GMO, Allergen-Free Carrier on Request | Food Sanitation Act Disclosure | PCR Identity & Flowability Index |
Importing botanical extracts into Yokohama necessitates meticulous document synchronization. The Yokohama Port Quarantine Station enforces strict oversight regarding biological safety, taxonomic identification, and non-medicinal classification under the Pharmaceutical and Medical Device Act (PMD Act). Sirn Bio-Tech provides end-to-end documentation packages for every SKU: botanical authority confirmation certificates (Latin binominal identification signed by licensed TCM pharmacists), manufacturing process flow charts showing all extraction solvent ratios, and batch-specific Certificates of Analysis (COA) specifying non-animal testing verification and radiation-free provenance.
How Yokohama product developers integrate our functional botanicals into market-leading consumer products across Japan's most competitive beauty and healthcare categories.
Yokohama cosmetics laboratories demand gentle, plant-derived bio-actives that provide anti-inflammatory and cellular repair functions without destabilizing emulsified cream systems or delicate facial essences.
Our micronized botanical powders—such as Rose, Neem, and Citrus peel complex—are milled down to 100–200 mesh for seamless integration into facial wash powders, mud masks, and clarifying hydrogels. Water-soluble floral fractions like Osmanthus Flower Extract deliver clean, alcohol-free aroma and antioxidant flavonoids that align with Japan's "Skinimalism" and sensory skincare trends.
To qualify for Kinō-sei Hyōji Shokuhin notification, formulations must provide proven active compound concentrations supported by systematic clinical reviews and batch uniformity.
Our Olive Leaf Extract (standardized up to 40% Oleuropein via HPLC) and Lychee Extract (rich in bioavailable polyphenols) serve as premier ingredients for metabolic health, postprandial glucose moderation, and blood pressure management formulas. Sourced in standardized powder forms, they ensure complete stability within two-piece hard gelatin capsules and compression-molded tablet matrices.
Kanagawa's functional beverage and drink pouch manufacturers require botanical powders with complete, sediment-free cold water reconstitution and zero artificial dye requirements.
Spray-dried Cherry Powder and Rosa Roxburghii (Prickly Pear) Extract offer vibrant natural coloring alongside bioavailable natural Vitamin C, SOD (Superoxide Dismutase), and anthocyanins. These extracts blend smoothly into daily beauty collagen drink shots, portable jelly sachets, and functional effervescents without precipitating or masking delicate fruit flavors.
Combining the vast botanical resources of the Qinling Mountains with advanced academic testing facilities and strict export packaging standards.
Operating 2 standard production facilities with 4 industrial processing lines, 2 pilot-scale validation lines, and a specialized cleanroom workshop compliant with international cGMP standards.
Joint research laboratories with Xi'an Jiaotong University, Northwest University, and Xi'an University of Science and Technology, backed by 18 specialized engineers and 5 licensed TCM pharmacists.
In-house testing with High-Performance Liquid Chromatography (HPLC), Gas Chromatography (GC), and UV Spectrometry ensures every drum meets exact active assay, moisture, and microbial parameters.
Low MOQ starting from 1 kg in high-barrier vacuum aluminum foil pouches for R&D formulation trials, up to 25 kg fiber drum bulk container freight direct to Yokohama Port.
Essential technical and regulatory guidance for purchasing managers and QA specialists across Kanagawa Prefecture.
Every agricultural harvest is screened before processing using multi-residue GC-MS/MS and LC-MS/MS testing protocols covering over 450 pesticide compounds. Our internal detection thresholds strictly enforce the default uniform limit of 0.01 mg/kg (0.01 ppm) established by Japan's Ministry of Health, Labour and Welfare (MHLW). Third-party validation reports from internationally accredited testing laboratories (such as SGS or Eurofins) are readily supplied alongside our factory COA prior to export dispatch.
We supply a comprehensive Japanese customs clearance compliance bundle with every consignment. This includes: (1) Official Batch Certificate of Analysis (COA) specifying botanical origin and Latin binomial name, (2) Non-Irradiation Certificate confirming zero gamma-ray or electron beam treatment, (3) Detailed Manufacturing Flow Chart detailing non-toxic solvent extraction and temperature controls, (4) BSE/TSE-Free and Allergen Declarations, and (5) Non-Animal Testing Statements tailored for cosmetic raw materials.
For urgent R&D samples and pilot-scale trials (1 kg to 25 kg), we ship via air express (FedEx/DHL) arriving at Tokyo Haneda (HND) or Narita (NRT) airports within 3 to 5 business days, clearing customs swiftly for courier delivery throughout Yokohama. For commercial scale volume (100 kg to full container loads), goods are routed via sea freight out of Qingdao or Shanghai maritime terminals directly to the Port of Yokohama (Honmoku/Daikoku Pier), taking approximately 7 to 10 days transit time.
Yes. In our cGMP extraction and spray drying workshop, we can modify particle size distribution from 60 mesh granulates up to 300 ultra-fine micronized mesh depending on whether your application is a high-speed tablet press, dry powder stick pack, or clear cosmetic dispersion. For fruit and vegetable powders, we offer both 100% pure carrier-free freeze-dried forms and spray-dried versions with customized non-GMO maltodextrin, resistant dextrin, or organic acacia gum carriers.
We routinely provide 50g to 200g complimentary sample units for qualified formulation and QA laboratories in the Yokohama and Tokyo metropolitan areas. Samples are sealed in air-tight aluminum foil pouches accompanied by the exact batch analytical COA, allowing your analytical department to perform HPLC marker verification, solubility testing, and micro-contaminant assays internally.
Connect with our technical export division. Whether you are formulating an innovative Kinō-sei Hyōji Shokuhin health tablet, a clean-label J-Beauty skincare line, or an instant functional beverage, our team will provide full specification sheets, batch COAs, and competitive CIF Yokohama quotations within 2 hours.
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