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Precision Botanical Portfolio
Standardized Extracts & Natural Powders Available for Direct Institutional Export
In addition to our flagship Icariin extracts, Xi'an Sirn Bio-Tech Co., Ltd. provides laboratory-verified functional ingredients manufactured in ISO, GMP, and university-partnered analytical facilities. All botanical substances meet stringent European safety levels regarding residual solvents, pesticide screening, and heavy metal limits.
Phytochemical Architecture
Standardized Epimedium (Horny Goat Weed) Science: Icariin & Flavonol Glycosides
Horny Goat Weed, known botanically under the genus Epimedium (chiefly Epimedium brevicornu Maxim. and Epimedium sagittatum [Sieb. et Zucc.] Maxim.), is an ancient botanical asset whose contemporary therapeutic relevance is driven by specific prenylated flavonol glycosides. Chief among these bioactive markers is Icariin (molecular formula: C33H40O15; CAS registry number: 489-32-7; molecular weight: 676.66 g/mol), a 8-prenyl derivative of kaempferol 3,7-O-diglucoside.
Chromatographic Purity & Analytical Control: In our Xi'an analytical testing center, every production run of Horny Goat Weed Extract Powder is tested through High-Performance Liquid Chromatography (HPLC) paired with a Photodiode Array Detector (PDA) at a detection wavelength of 270 nm. Our calibration matches international pharmacopoeial standards (European Pharmacopoeia Ph. Eur., USP botanical monographs, and ChP), confirming not only active Icariin yield but also tracing related bioactive congeners including Epimedin A, Epimedin B, Epimedin C, and Icariside II.
The pharmacodynamics of Icariin are well-documented across biomedical literature. As an endogenous phosphodiesterase type 5 (PDE5) inhibitor, Icariin promotes cyclic guanosine monophosphate (cGMP) accumulation, supporting vascular smooth muscle relaxation and microvascular endothelial integrity. Simultaneously, Icariin exhibits marked osteogenic and osteoprotective mechanisms through the upregulation of bone morphogenetic protein-2 (BMP-2), Runx2, and alkaline phosphatase (ALP) expression in human osteoblast precursors, counteracting osteoclastic bone resorption. These dual vascular and skeletal pathways position standardized Epimedium powder as a premier raw material for senior vitality blends, bone density supplements, and targeted microcirculatory remedies.
| Standard Grade | Assay Method | Active Marker | Physical Properties | Solubility Profile | Recommended Application |
|---|---|---|---|---|---|
| Herbal Extract 10:1 / 20:1 | TLC / UV | Whole Spectrum Glycosides | Fine Brownish-Yellow Powder (80 mesh) | Partially water soluble, hydroalcoholic | Traditional decoctions, tea infusions, tonics |
| Standardized Icariin 10% | HPLC (Isocratic elution) | Icariin ≥ 10.0% | Light Brown-Green Powder (80-100 mesh) | Dispersible in water/alcohol blends | Encapsulation, broad vitality formulas |
| Standardized Icariin 20% | HPLC (External standard) | Icariin ≥ 20.0% | Yellow-Brown Powder (100 mesh) | Soluble in ethanol, warm water dispersion | Targeted cardiovascular & bone formulations |
| Standardized Icariin 50% | HPLC (Reverse Phase C18) | Icariin ≥ 50.0% | Light Yellow Powder (100 mesh) | Soluble in ethanol, ethyl acetate, DMSO | High-potency clinical & nutraceutical tablets |
| High-Purity Icariin 98% | HPLC (Gradient RP-HPLC) | Icariin ≥ 98.0% | Pale Yellow Crystalline Powder | Soluble in polar organic solvents, methanol | Biomedical research, clinical reference material |
Regional Context & Institutional Integration
Localized Application Scenarios Serving the Vatican & Roman Healthcare Environs
Procurement intended for distribution within the Vatican City State (Stato della Città del Vaticano) and associated ecclesiastical or health institutions around Rome demands an exceptional standard of purity, ethical provenance, and documented safety.
Farmacia Vaticana & Clinical Dispensaries
The historic Vatican Pharmacy (Farmacia Vaticana), serving thousands of patrons daily with medicines and specialty dietary health aids unavailable in standard Italian domestic shops, requires raw ingredients that possess comprehensive toxicological documentation, allergen control, and full compliance with the European Directorate for the Quality of Medicines (EDQM) guidelines.
Monastic Herbalism & Tonic Formulations
Monastic religious orders and Pontifical colleges operating botanical dispensaries emphasize venerable, naturally derived remedies adapted for modern preventative care. Standardized Epimedium extract powder is incorporated into specialized wellness teas, adaptogenic syrups, and natural geriatric vitality capsules targeted at cognitive clarity, bone density support, and physical restoration.
Pontifical Research & Ethnomedicinal Studies
Academic medical researchers and biomedical faculty across Roman pontifical universities utilize our ultra-pure 98% Icariin and defined ratio extracts for in vitro study of osteogenesis, PDE5 kinase signaling, neuroprotective anti-inflammatory pathways, and bio-gerontological cellular longevity models.
Regulatory Integrity & Export Verification
CE Conformance, European Traceability & Safety Compliance
Exporting botanical extracts to entities operating within the European trade corridor and serving sovereign enclaves like Vatican City necessitates rigorous adherence to EU standards. While botanical powders destined for dietary use are regulated under European food safety directives, our CE conformity covers the specialized processing methodology, analytical clean-room equipment, and Good Manufacturing Practice (GMP) qualification of our extraction infrastructure.
Contaminant Thresholds (EC 2023/915)
Every lot conforms to strict European maximum levels for heavy metals: Lead (Pb) < 3.0 mg/kg, Cadmium (Cd) < 1.0 mg/kg, Mercury (Hg) < 0.1 mg/kg, and Arsenic (As) < 1.0 mg/kg (tested via ICP-MS).
Pesticide Multiresidue Screen
Full spectrum testing via GC-MS/MS and LC-MS/MS following Regulation (EC) No 396/2005. Free from organophosphates, pyrethroids, and chlorinated hydro-carbons.
Ethylene Oxide (EtO) & Irradiation
100% Non-irradiated and guaranteed Non-EtO (Ethylene Oxide / 2-Chloroethanol < 0.05 mg/kg) treated, verified by accredited third-party laboratories (Eurofins / SGS on request).
Clean-Label & Non-GMO
Naturally harvested without genetic engineering. Free from artificial colorants, synthetic carriers (maltodextrin-free options available), and common allergens according to EU 1169/2011 Annex II.
Industrial Scale & University Joint Laboratories
Xi'an Sirn Bio-Tech: Advanced Botanical Extraction Infrastructure
Headquartered in the historic herbal medicine cradle of the Qinling Mountains corridor in Xi'an, Shaanxi, Xi'an Sirn Bio-Tech Co., Ltd. marries deep botanical heritage with modern industrial precision.
Standardized Production Lines
Operating 4 continuous industrial extraction lines and 2 flexible pilot lines inside our GMP-compliant workshop. Our pilot setups allow seamless scaling from initial laboratory trials (1 kg) to multi-ton commercial manufacturing without varying extraction selectivity, thermodynamic heat profiles, or solvent recovery parameters.
Independent Analytical Center
Equipped with in-house High-Performance Liquid Chromatography (HPLC), Gas Chromatography (GC), Atomic Absorption Spectroscopy (AAS), UV-Vis Spectrophotometry, and thin-layer chromatography (TLC). We guarantee chemical identity, exact assay potency, moisture, ash, and microbiological specs before any batch is sealed.
Academic Collaboration
We maintain active joint research laboratories with Xi'an Jiaotong University, Northwest University, and Xi'an University of Science and Technology. Staffed by 18 senior and mid-level chemical technicians and 5 licensed Traditional Chinese Medicine (TCM) pharmacists.
Process Quality Engineering
Traceable 8-Step Manufacturing Process for Standardized Icariin
To ensure batch-to-batch consistency and total traceability for institutional clients in Vatican City and across Europe, our Horny Goat Weed Extract follows an 8-stage manufacturing architecture:
Step 1: Raw Herb Selection
Wild-crafted and GAP-cultivated Epimedium brevicornu aerial leaves sourced directly from certified mountainous Shaanxi habitats; macroscopically and TLC authenticated by senior licensed TCM pharmacists.
Step 2: Incoming QC Screen
Moisture testing, foreign botanical matter elimination, particle pre-sizing, and mandatory rapid testing for heavy metals and residual agricultural contaminants prior to silo release.
Step 3: Multi-Stage Extraction
Controlled dynamic counter-current solid-liquid extraction utilizing food-grade hydroalcoholic solvent mixtures under monitored temperatures (50–65°C) to prevent thermal degradation of vulnerable flavonol glycosides.
Step 4: Filtration & Vacuum
Centrifugal separation followed by multi-stage cartridge microfiltration. Low-temperature falling-film vacuum evaporation concentrates the liquor while preserving heat-sensitive polyphenols.
Step 5: Macroporous Resin Fraction
Chromatographic resin adsorption (D101/AB-8) column processing separates Icariin and related flavonols from crude sugars and tannins, escalating active marker purity up to specified concentrations.
Step 6: Low-Temp Spray Drying
Aseptic atomization inside a closed-circuit spray drying tower using purified nitrogen blanket, yielding uniform micro-granules (80–100 mesh) with minimal moisture content (≤ 5.0%).
Step 7: In-House HPLC & COA
Quantitative HPLC assay determination for Icariin, moisture, total heavy metals (ICP-MS), total plate count, yeast/mold, E. coli, and Salmonella negative clearance. Batch COA finalized.
Step 8: Double-Sealed Packaging
Dispatched in double food-grade polyethylene interior liners hermetically heat-sealed inside multi-layer aluminum barrier bags (1 kg/bag) or clean-room packed fiber drums (25 kg/drum).
Procurement Intelligence
Frequently Asked Questions by Institutional Buyers Serving the Vatican
Direct, transparent solutions addressing custom formalities, analytical validation, and distribution channels into Rome and the Vatican City State.
Q: How is delivery managed for institutional orders destined for the Vatican?
Vatican City State operates a unique customs corridor through the surrounding territory of the Italian Republic (Rome). Shipments of Horny Goat Weed Extract are dispatched via priority air freight (DHL Express, FedEx, or specialized air cargo) routed to Rome Fiumicino (FCO) or Ciampino (CIA) hubs. We provide full commercial invoicing, Air Waybills, packing lists with Harmonized Tariff Schedule (HTS) code 1302.19, and full Certificate of Analysis (COA) documentation to ensure frictionless release through Italian and Vatican customs points.
Q: What is the Minimum Order Quantity (MOQ) for custom Icariin specifications?
Standard in-stock Icariin powders (such as 10%, 20%, and 50% HPLC or 10:1/20:1 ratios) carry an accessible 1 kg MOQ. This enables monastic dispensaries, research faculties, and bespoke supplement formulators to execute pilot trials and internal QC assays without excessive capital commitment. Custom specifications requiring tailored mesh sizes (e.g., ultra-fine 200 mesh) or specific carrier-free blends start at 25 kg (one standard fiber drum).
Q: Which technical and safety dossiers are provided with each order?
Every dispatch is accompanied by a comprehensive batch-specific Certificate of Analysis (COA) signed by our Chief Quality Officer. On request, we provide Material Safety Data Sheets (MSDS / SDS in Italian or English), Technical Specification Sheets (TDS), Process Flow Charts, Allergen Free Statements, Non-GMO Declarations, TSE/BSE Non-Contamination Certificates, and third-party laboratory verification for ethylene oxide (EtO) and pesticide screening.
Q: Can Xi'an Sirn Bio-Tech supply private-label and OEM formulations?
Yes. Beyond supplying raw bulk active powders, our OEM/ODM manufacturing facility supports finished formats. We engineer customized capsule formulations combining standardized Horny Goat Weed Extract with synergistic botanicals (e.g., Maca, Ginseng, Cordyceps, or Rosehip), sachet packing, and custom-labeled pharmaceutical-grade blister packaging manufactured to your exact brand specifications.
Request Batch Documentation, Samples & Technical Pricing
Whether you are formulating a new dietary supplement line, stocking an institutional pharmacy, or conducting phytochemical research, our technical team provides HPLC chromatograms, full COAs, and competitive FOB/CIF quotation within two hours.
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